![]() PEA appears to be produced on demand in areas of local inflammation including, according to its proponents, inflammation in the brain. The authors reported that the “ultra-micronized” form used in this study maximizes PEA bioavailability and allows it to penetrate through the blood–brain barrier and into the brain. When taking PEA for depression, try 600 mg twice a day. Michael Murray reports that 300-600 mg a day are recommended, with 600 mg being more effective in pain studies. (Health Rising does not derive any funds from the sale of Mirica.) It is available on Amazon as Mirica in the U.S. Still, PEA-LUT’s potential – tamp down mast cell activation and neuroinflammation – makes it intriguing.We lack the kind of large, well put together studies that we can count on. It’s certainly gathered some interest and the findings are generally good, but the studies are usually small and often lack real rigor. PEA-LUT is in a kind of in-between area.The authors did not assess where the patients experienced symptom improvement.Indeed, although the long-COVID patients experienced cognitive problems, the tests suggested that cognitively they were normal. Since specific tests are needed to uncover the cognitive abnormalities in ME/CFS, the researchers may have used the wrong tests. However, the tests used to measure cognition were not specific to the types of cognitive issues found in a disease like ME/CFS or long COVID. ![]() It did not appear to improve cognition.The study found that GABA nervous system transmission was low in long COVID and that PEA-LUT increased GABA functioning. ![]() Low PEA-LUT and endocannabinoid levels have been hypothesized to open the door for neuroinflammation. PEA-LUT appears to be a “balancer” its produced locally in the body in response to stress and helps to return the body back to homeostasis.Animal studies and some clinical trials suggest that PEA-LUT may be able to tamp down neuroinflammation and mast cell activation and reduce pain and possibly help in several neurodegenerative diseases.Low GABA levels are associated with insomnia, and anxiety and difficulty turning off the stress response.Another study examined the effects of PEA-LUT – a food supplement – on GABA functioning in the brain and cognition in long COVID.A recent study found that the brain fog in long COVID is very similar to that found in chronic fatigue syndrome (ME/CFS).Recently, a different approach to cognitive health popped up in a small long-COVID trial. ![]() Jon Kaiser, MD – the creator of the protocol – produced a caffeine-plus-mitochondrial supplement for those who don’t want to, or can’t, try the stimulant drug approach. Methylphenidate plus mitochondrial enhancers did improve cognitive symptoms as well as fatigue, sleep, and pain in a small GWI study. With the exception of some stimulants (Vyvanse, methylphenidate), no drugs to my knowledge have been found to help cognition. (That said, the people with ME/CFS generally had worse cognitive scores than the long-COVID patients.)īut what to do about brain-fog – one of the most troubling symptoms in both diseases? The big clinics, of course, don’t have a clue. The authors believed that a reduction in the capacity to maintain attention, and a lower processing speed, underlaid all other cognitive complaints in both diseases. Note what a nice, coherent package this is: not being able to process information quickly makes it difficult to sustain attention, which impacts memory and the ability to learn. Sustained attention capacity, processing speed, memory, and ability to learn were primarily affected in both groups. The answer to a recent study’s question, “ Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?” was yes. Ditto with Harvard Health – (“ What is COVID-19 brain fog - and how can you clear it?“), Healthline ( “What to Know About COVID-19 and Brain Fog“), WebMD (“ Fatigue, Brain Fog Most Common in ‘Long COVID“), and others.Ī “thank you” is also in order to the massive long-COVID community a big thank you for validating symptoms like post-exertional malaise and brain fog that languished in our corner of the medical field for decades but thanks to you, and your advocacy and your pain, have become commonplace and believed. The Mayo Clinic – which historically has been no friend at all to ME/CFS but is showing signs of changing – has adopted it (“ Brain fog from long COVID-19 “). “Brain-fog”: it’s another descriptive birthed by the chronic fatigue syndrome (ME/CFS) community that’s been seamlessly by adopted the long-COVID community (you’re welcome!). Brain-fog: no need to create another term – the original says it all. ![]()
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